Even though individuals are getting vaccinated, severe Covid-19 remains a significant risk for some individuals because of damaged lungs. Those people who needed ventilators have a mortality risk of 40%.  The immune system is over exerted in its attempt to ward off the virus.  Cytokines CCL2 and CCL3 are excessive in their response and role in attracting immune cells into the lungs.  Somatostatin has the ability to stop cytokines getting to levels where terminology such as storms or hail, are used.  Basically, somatostatin modulates Glia cells, which includes microglia.  Microglia activation can result in the secretion of CCL3 and the production of CCL2.  The relationship between microglia and somatostatin is close.  Somatostatin is also needed (among many things) when growth hormone is released.  This is important because it shuts down any unregulated cell development and is found at many tumor sites.  With these attributes cytokines can’t be damaging and could be said to be (somatostatin) ante-inflammatory in a sense.  What has happened to Somatostatin?

As the virus mutates and different variants present, there will be continuously evolving scenarios.

https://www.eurekalert.org/pub_releases/2021-03/cuim-isc031521.php