The second dementia scenario is Lewy Bodies. 

If dopamine levels stay high for a prolonged

period and somatostatin can’t reel the

catecholamine in, the brain then tries to rectify

 the situation.  A new study has found that Lewy

Bodies has been associated with the deposition of

amyloid beta.  The possibility of a very close relationship between the two and how they form is intriguing.  The formation of a Lewy Body may be associated with an amyloid beta plaque. Alpha synuclein binds to membranes if dopamine is high.  Neprilysin with Lewy Bodies is also low again like Alzheimer’s. This indicates that somatostatin cannot degrade a Lewy Body as it is a completely different entity.  To be clear, it is not able in this situation to undermine the process of the development of a Lewy Body.  However, the substantia nigra and the basal ganglia, locus coeruleus slowly become overwhelmed with Lewy Bodies.  As the disease progresses it moves into the cortex.  The substantia nigra produces dopamine which controls movements and muscle tone.  The locus coeruleus is a nucleus in the pons of the brainstem involved with physiological responses to stress and panic.  Lewy Bodies do all of this for a reason.  The original scenario was high dopamine.  Lewy Bodies reduce the production of dopamine and alpha synuclein decreases insulin resistance through increasing glucose uptake by adipocytes and muscles.  As dopamine levels slide, the symptoms of Parkinsons become more pronounced.  It often starts with a tremor in one hand.  As time goes by other symptoms such as slow movement, stiffness and loss of balance become apparent.  Too many symptoms to list.  With the slide of dopamine there are many other levels that decrease with it; 1) serotonin 2) cortisol 3) glutamate 4) possibility of endorphins.  Melanocyte stimulating hormone has a knock-on effect with the catecholamines.  Somatostatin levels stay low as they have always been through these illnesses.  Somatostatin is very effective at controlling spiking dopamine levels but can do little to stop plummeting levels, except by staying low.  Eventually if there is a disconnect between somatostatin and dopamine there is no control within the brain by these two entities.  This is why somatostatin and dopamine need a healthy relationship.